Enhanced Na(+)-Ca2+ exchange activity in cardiomyopathic Syrian hamster.

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Enhanced Na(+)-Ca2+ exchange activity in cardiomyopathic Syrian hamster.

The signaling of contraction by Ca2+ in the Syrian hamster (BIO 14.6) heart in the late stage of the cardiomyopathy (220 to 300 days old) was compared with that in age-matched healthy hamster hearts. Membrane current and cell shortening or intracellular Ca2+ transients were measured simultaneously in isolated whole-cell-clamped myocytes. The density of the L-type Ca2+ current was smaller in myo...

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Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster.

The Syrian cardiomyopathic hamster (SCH) is an established animal model for genetic cardiomyopathy. The disease in the hamster develops through similar stages to those observed in humans with this condition. The pathophysiological basis for this condition in the hamster resides in an inherited mutation in the gene encoding for delta-sarcoglycan, a component of the dystrophin complex. Two basic ...

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Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses.

Although abnormal myocardial calcium homeostasis in the cardiomyopathic hamster (CMH) has been documented in the hypertrophic stage of the disease, the Ca2+ tolerance before the hypertrophic stage has not been investigated. We studied isovolumic contractile function in response to a variety of Ca2+ stresses including increases in perfusate [Ca2+] (Cao), the Ca2+ channel agonist Bay K 8644, and ...

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Increased compliance in diaphragm muscle of the cardiomyopathic Syrian hamster.

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1994

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.74.2.253